Figure 1

Allograft tumors in CIB1-KO mice are smaller and have a distinct morphological appearance. (a) Two representative images of B16 melanoma tumors or Lewis lung carcinoma tumors that developed after 14 days in either WT or CIB1-KO mice. Tumors in CIB1-KO mice had a distinct morphological appearance, with gross necrosis of melanoma tumors and blanching of carcinoma tumors. (b, c) Tumors that developed in CIB1-KO mice were smaller in volume and weight compared to WT mice, but no significant difference was noted for melanoma tumor weight. Error bars are ± SEM (n = 8-11 mice per group; * p < 0.05).