Table 1 Signaling pathways/factors that regulate Notch ligand expression in vascular endothelial and smooth muscle cells
From: Novel insights into the differential functions of Notch ligands in vascular formation
| Pathway/factor | Ligand | Cell type | Biological effect | References |
|---|---|---|---|---|
| VEGF | Dll4 (↑) | Endothelial cells | Arterial specification | [22, 24, 27] |
| Endothelial tip cell formation in sprouting angiogenesis | [23, 25, 26, 28] | |||
| TNFα | Dll4 (↓) Jagged1 (↑) | Endothelial cells | Tip cell and stalk cell selection | [52] |
|
VEGF + FGF2 (synergistic) | Dll1 (↑) | Endothelial cells | Ischemia-induced postnatal arteriogenesis | [38] |
| PDGF/angiotensin II | Jagged1 (↓) | Smooth muscle cells | Growth regulation | [45] |
| Jagged1 (endothelial) | Jagged1 (↑) | Mural cells | Smooth muscle cell maturation | [21] |