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Figure 7 | Journal of Angiogenesis Research

Figure 7

From: Novel insights into the differential functions of Notch ligands in vascular formation

Figure 7

Opposing effects of Dll4 and Jagged1 on sprouting angiogenesis. VEGF signaling induces Dll4 expression in tip cells, and Dll4, in turn, activates Notch signaling in stalk cells, which reduces stalk-cell sensitivity to VEGF stimulation and, consequently suppresses the tip-cell phenotype. Conversely, Jagged1 antagonizes Dll4-mediated Notch activation in stalk cells to increase tip cell numbers and enhances vessel sprouting. The antagonistic effects of the two ligands are controlled by Fringe-dependent modulation of Notch signaling.

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