Table 5 Alterations in biomarkers induced by chemotherapy in breast cancer patients remaining free of VTE within three months of chemotherapy
Coagulation marker | Pre-chemo [n] | Day 1 (post chemo) [n] | Day 4 (post chemo) [n] | Day 8 (post chemo) [n] | 3 months (post chemo) [n] |
|---|---|---|---|---|---|
sVEGF μg/ml, geometric mean (CI) | 212.4 (185.6-243.1) [110] | 197.5 (171.1-228.0) [103] | 152.8 (131.7-177.4) [103] | 148.3 (126.8-173.3) [105] | 228.0 (197.4-263.4) [100] |
pVEGF μg/ml, geometric mean (CI) | 15.4 (13.5-17.7) [108] | 14.5 (12.9-16.4) [104] | 16.0 (13.7-18.7) [101] | 20.2 (18.0-22.7) [103] | 21.9 (18.8-25.5) [97] |
Platelet count × 109/l, mean (CI) | 311.6 (295.2-328) [111] | 302.4 (283.4-321.4) [89] | 262.5 (248.1-277) [97] | 239 (223.4-254.5) [106] | 302.5 (279.6-325.5) [102] |
Platelet VEGF VEGF μg/ml per platelet × 109 median (range) [n] | 0.61 (0.52-0.71) [108] | 0.58 (049-0.69) [89] | 0.49 (0.41-0.58) [97] | 0.52 (0.43-0.62) [103] | 0.70 (0.61-0.81) [97] |