Platelet release of Vascular Endothelial Growth Factor (VEGF) in patients undergoing chemotherapy for breast cancer

Table 4 Alterations in biomarker parameters induced by chemotherapy in breast cancer patients developing VTE within three months of chemotherapy

Coagulation marker	Pre-chemo [n]	Day 1 (post chemo) [n]	Day 4 (post chemo) [n]	Day 8 (post chemo) [n]	3 months (post chemo) [n]
sVEGF μg/ml, geometric mean (CI)	282.6 (136.5-585.3) *[11]*	267.8 (136.5-525.4) *[11]*	220.1 (110.7-437.3) *[11]*	226.0 (116.3-439.2) *[11]*	358.8 (116.3-774.2) *[9]*
pVEGF μg/ml, geometric mean (CI)	27.8 (14.3-54.1) *[12]*	19.5 (10.4-36.6) *[11]*	19.0 (9.4-38.3) *[11]*	23.4 (13.2-41.5) *[11]*	18.7 (13.7-25.5) *[9]*
Platelet count × 10⁹/l mean (CI)	342.5 (265.8-419.2) [12]	338.9 (246.4-431.4) [10]	269.6 (225.5-313.8) [11]	274 (216.8-331.2) [11]	386.2 (238.3-534.1) [10]
Platelet VEGF VEGF μg/ml per platelet × 10⁹ median (range) [n]	0.89 (0.42-1.87) [11]	0.89 (0.47-1.68) [10]	0.86 (0.39-1.86) [11]	0.83 (0.39-1.75) [11]	1.02 (0.53-1.97) [9]

ISSN: 2045-824X