Table 2 Baseline biomarker results prior to chemotherapy

sVEGF μg/ml, geometric mean (CI)[n]

344.0 (270.7-437.2)*† [35]

181.0 (155.9-210.2)* [86]

28.8 (25.3-32.8)† [61]

<0.001

(*<0.001, †<0.001)

pVEGF μg/ml, geometric mean (CI)[n]

22.8 (17.6-29.4)*† [35]

14.2 (12.1-16.6)* [86]

15.1 (12.7-17.9)† [61]

0.004

(*0.01, †0.03)

Platelet count × 10⁹/l, mean (CI) [n]

326.7* (286.9-366.5) [36]

309.6 (293.0-326.2) [87]

278.6 (257.7-299.6)* [45]

0.04

*0.05

Platelet VEGF VEGF μg/ml per platelet × 10⁹

median (range) [n]

1.02*†‡ (0.17-3.53) [35]

0.53* (0.05-2.89) [83]

0.53 ‡(0.007-2.48) [45]

0.05

(*<0.001, †0.008,

‡0.002