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Figure 4 | Journal of Angiogenesis Research

Figure 4

From: DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study

Figure 4

Example parameter maps calculated from MRI data. Both patients received vandetanib 300 mg and had RECIST-defined progressive disease on day 57 (patient 1983, Panel a) and day 62 (patient 2999, Panel b). Only the cutout of the lesion is shown. Definitions: Ktrans volume transfer constant between blood plasma and extravascular extracellular space Ve, extravascular extracellular volume fraction; Unfit image pixels, which could not be fitted by DCE-MRI models (low uptake of contrast agent); iAUC60 initial area under the DCE-MRI contrast agent concentration--time curve after 60 s; R10 native longitudinal relaxation rate constant before contrast agent administration;T2* effective transverse relaxation time.

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