Figure 1

A-B) CD105 positive neovessels in a grade V carotid plaque from a patient who had undergone endarterectomy. Grading was based on the classification of Stary [67]; lipid containing plaques with evidence of inflammation and angiogenesis) Only selected microvessels are CD105 positive in these lesions suggesting a dynamic feature of angiogenesis within the plaque architecture. A is × 40 and B × 100. C) Shows expression of immature neointimal vessels composed of only endothelial cell lining and stained positive for CD105 (black arrows), in contrast to more mature vessels negative for CD105 and possessing a smooth muscle cell coating (red arrows) Photomicrographs are × 100. D) Shows morphologically distinct multilobulated abnormally developing vessels again, stained positive for CD105 without smooth muscle cell or pericyte involvement in the neointima of a grade V plaque (× 100).