Figure 1
From: Lymphangiogenesis and angiogenesis during human fetal pancreas development
Angiogenesis during human pancreatic development. (A) Haematoxylin and eosin (H&E) staining of pancreata at W11, W17 and W22 illustrating the two types of mesenchyme, the peri-pancreatic mesenchyme (PPM) and intra-pancreatic mesenchyme (IPM). The pancreatic epithelium is embedded in the IPM. (B) Pancreata at W9, W11 and W19 immunostained for CD31 and CK19. White line in the top panel shows the separation between the PPM and IPM. White arrows point to CD31-positive blood vessels. (C) Pancreas at W9 immunostained for endoglin (ENG) and CK19. (D) Pancreata at W12, W19 and W22 immunostained for CD31 and glucagon (GLG, α-cells). Dashed line shows the islet of Langerhans. White arrows point to capillaries. (E) Pancreata at W12, W14.5, W19 and W21 immunostained for CD31 and insulin (INS, β-cells). Note that autofluorescent red blood cells, as yellow/orange dots, are present in in all images. Scale bars: (A, left panel) 200 μm, (A, middle and right panel) 1 mm, (B-E) 30 μm.