Figure 9
From: Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis
Effect of lithium chloride on the activity of MMP-2 and MMP-9. HUVECs were maintained in culture with 10 μM curcumin for 48, 72 and 96 hrs as described in text with and without GSK-3 inhibitor lithium chloride 1 mM. Medium was removed and the activities of MMP-2 and MMP-9 were determined by gelatin zymography. The intensity of MMP-9 and MMP-2 were measured and expressed in intensity units/mm2/mg protein. * Statistically significant when compared to untreated control p < 0.05.