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Figure 3 | Vascular Cell

Figure 3

From: Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential

Figure 3

AD-MSC-CM possess a higher capacity to stimulate HUVECs and HMECs proliferation and tube formations compare to HNDFs-CM. The effect of AD-MSCs-CM and HNDFs-CM on proliferation of HUVECs (A) and HMECs (B) was tested by adding different dilutions to EGM control medium. As a positive growth control, we used VEGFa 10 ng/ml. AD-MSCs-CM addition had a great capacity to stimulate the proliferation of HMECs (B) and to a minor extent HUVECs (A), while HNDFs-CM addition did not affect ECs proliferation at any dilution tested. In (C) and in (D) are shown the capacity of AD-MSCs-CM and HNDFs-CM to induce HMECs tube formation respectively. AD-MSCs-CM and HNDFs-CM were added at a ratio 1:1 with EGM control medium (Magnification 10×). Note that AD-MSCs-CM not only increased HMECs tube formation on day 2, but also delayed their regression on day 5. The columns in (A) and (B) are mean ± SD of three independent experiments run in triplicate. *p < 0.05 and **p < 0.01 versus CTRL.

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Vascular Cell

ISSN: 2045-824X

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